Structure-based drug design studies of the interactions ofent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparumsarco/endoplasmic reticulum Ca2+-ATPase PfATP6
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چکیده
منابع مشابه
Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca2+-ATPase PfATP6
Malaria is responsible for more deaths around the world than any other parasitic disease. Due to the emergence of strains that are resistant to the current chemotherapeutic antimalarial arsenal, the search for new antimalarial drugs remains urgent though hampered by a lack of knowledge regarding the molecular mechanisms of artemisinin resistance. Semisynthetic compounds derived from diterpenes ...
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A recent reinvestigation of aerial parts of Wedelia paludosa D.C. is described and reports, for the first time, the isolation of iso-kaurenoic acid from this species.
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In this article the morphology of sarcoplasmic reticulum, classification of Ca(2+)-ATPase (SERCA) isoenzymes presented in this membrane system, as well as their topology will be reviewed. The focus is on the structure and interactions of Ca(2+)-ATPase determined by electron and X-ray crystallography, lamellar X-ray and neutron diffraction analysis of the profile structure of Ca(2+)-ATPase in sa...
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15 صفحه اولKaurane-Type Diterpenes from Fern Frond Exudates
The viscid exudate found on fronds o f the fern, Cheilanthes kaulfussii, consists of terpenoids in which flavonoid aglycones are dissolved. One of the terpenes is shown to be em-kaur-16-en-19-oic acid. The farinose frond exudate of Notholaena pallens contains this acid as the major constituent and its 3 /?-hydroxy derivative, together with flavonoid aglycones as minor components. In N. incana, ...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2015
ISSN: 0074-0276
DOI: 10.1590/0074-02760140415